Description

Sleep deprivation impairs spatial, emotional, and working memories, and augments anxiety-like behaviors.

The walking model of sleep deprivation apparatus from MazeEngineers is an automated device that provides movement at researcher programmed intervals to prevent REM sleep. This model prevents sleep using a sweeping bar at the bottom of the chamber.

Safe to use for up to 8 rodents, food and water apparatuses are available to allow long-term experimentation. Please note that this is one of two possible sleep deprivation models, the other being the chamber sleep deprivation apparatus

Features

Chamber

• Clear rectangular chamber
• Chamber dimensions: Outside: 16.0”L x 11”W x 15” H, Inside Living Space: 9”L x 8”W x 8” (custom dimensions are available)
• Sweeping bar
• Safe for animal use
• Each apparatus can operate 8 mice or rat simultaneously
• Includes both water and food supplies for long-term sleep deprivation.

Motor

• Operating speed: 1-100 m/min,
• High response speed (1ms), quiet <30dB noise level,
• Closed loop feedback control. High control accuracy, real-time performance, speed control range 0-100m/min , precision 0.01m/min
• Measurement accuracy: cm measurement, < ±0.1% .
• Acceleration, reversal and rest time free settings

Control

• Full color touch screen manual operation
• Uniform acceleration and uniform deceleration
• Running and rest time can be cycled
• Data browsing and printing: The system automatically saves 50 sets of experimental data, the experimenter can browse any experimental data, export and print to computer for post processing available.
• Automatic data storage, COM interface and computer connection.
• 220V single phase, frequency 50Hz , total power 200W
• Weight: 25kg

Data Upload

• Conductor software control and data analysis
• The software can freely add protocols, set the forward motion, reverse motion, and rest time
• Adjustable sound frequency
• Running and rest time can be cycled
• Data browsing and printing: The system automatically saves 50 sets of experimental data, the experimenter can browse any experimental data, export and print to computer for post processing available.
• Automatic data storage, COM interface and computer connection.
Conductor software

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Price & Dimensions

Sleep Deprivation

$ 4900

Per Month
  • Rectangular clear chamber with sweeping bar
  • LCD touch screen
  • Conduct software for protocol set-up and data upload and analysis

Geotaxis Test

Grid Test

Horizontal Grid Test

Stairway Test

Triple Horizontal Bars

Static Rods

Apparatus and Equipment

 

The Sleep Deprivation Chamber consists of a rectangular plexiglass cage. A sweeping bar is present at the base of the cage that can be controlled by software to allow the desired speed to move to disturb the subjects’ sleep as the bar touches their feet.

Documentation

Sleep is essential for the normal functioning of humans. The lack of sleep causes cognitive deficits in waking cognitive functions, observed as the inability to focus, think with clarity, and sustain attention (Worley, 2018). Sleep deficits also have adverse outcomes in children, affecting their cognitive, physical, and socioemotional development (Schlieber & Han, 2021). Therefore, sleep deprivation and sleep fragmentation studies can examine how sleep deficits affect different domains in human cognition and behavior. The Sleep Deprivation Chamber can easily be used to study the effects of sleep deprivation on cognition and behavior using a rodent animal model. It can be used in conjunction with other behavioral testing apparatuses such as the Y-Maze and the Morris Water Maze.

The Sleep Deprivation Chamber also includes built-in food and water systems for long-term experimentation.  The chamber is large enough to accommodate multiple subjects to prevent social isolation stress and disrupt the sleep of several subjects simultaneously.

Training Protocol

Clean the cage. Refill the food and water containers when they are emptied.

Sleep Deprivation Task 

Place the subjects in pairs in the Sleep Deprivation Chamber to eliminate social isolation stress. Subject the rats to sleep deprivation for 6 hours a day for seven days. Increase the sleep deprivation duration to 8 hours per day after the seven days. Conduct trials for seven days with the sleep deprivation increment.

The increment in sleep deprivation is necessary for developing rats since the percentage of sleep during the light phase increases with age.

References

Schlieber M, Han J. The Role of Sleep in Young Children’s Development: A Review. J Genet Psychol. 2021 Jul-Aug;182(4):205-217. doi: 10.1080/00221325.2021.1908218. Epub 2021 Apr 7. PMID: 33825621.

Worley SL. The Extraordinary Importance of Sleep: The Detrimental Effects of Inadequate Sleep on Health and Public Safety Drive an Explosion of Sleep Research. P T. 2018 Dec;43(12):758-763. PMID: 30559589; PMCID: PMC6281147.